To kill these bacteria , while reducing the ability of human cells , cigarettes , as an alternative to a healthy electronic cigarette in the laboratory studies , and drug resistance , the manufacturer is potentially Despite being touted the increased bacterial virulence life-threatening .
Human epithelial cells electronic cigarette vapor methicillin-resistant Staphylococcus aureus (MRSA) and (ie , and (VASDHS) University of California, San Diego VA San Diego Medical Systems for the field test of the impact of cell in the cavity and multiple organs formed ( researchers at UCSD) body in vivo of the outer surface ) .
Usually , nasopharyngeal epithelial cells ( skin ) MRSA epithelial cells ( upper part is located at the rear of the upper throat, and nose ) , bacteria are exposed to inhaled agents as steam always like this , it is smoke electronic cigarette and form a colony .
Increase the electronic cigarette vapor , " toxic MRSA , said: researcher Dr. chief " associate professor of critical care medicine and pulmonary roller · E. Crotty Alexandria , Virginia , researcher , University of California, San Diego .
Exposure to electronic cigarette vapor , increases the virulence of bacteria that can help you escape the macrophage killing , MRSA and antimicrobial peptides . However , she added that not to perform aggressive bacteria such as cigarette smoke exposure in a parallel study her group went steam .
Process researchFor electronic cigarette vapor experiment , researchers of culture and inhalation is similar to the growth of the market of MRSA ( U.S. 300 ) the vapor concentration . After you test the culture that is the first known to promote the biochemical changes in the virulence of the pathogen , they will present the alveolar epithelial cells and macrophages kill the test .
The study, presented at the American Thoracic Society International Conference in 2014 , .
The growth rate , vulnerability to reactive oxygen species (ROS) , surface charge , hydrophobicity and biofilm formation : The researchers looked at the five factors contribute to the toxicity of MRSA. A change in biofilm formation surface and the state of charge of the electronic cigarette , vapor result in particular by providing a high resistance to antibiotics kill human cells and it .
AlkalineBy inducing a rapid change Alexander , of electronic cigarette vapor pH, Crotty said pathogenicity enhanced the possible contribution of staphylococci . Environment changes from a pH value of 7.4 to 8.4 exposure so that the ( alkaline pH) alkalosis very on mammalian cells and bacteria . Giving a danger signal to activate defense mechanisms to them , the alkalosis stressed cells .
In order to produce a binding antimicrobial peptides more actively them , in order to avoid the natural human immune cells fatal bacteria , to charge the surface . The bacteria , MRSA does not become vulnerable , to increase the viscosity thereof , to form a thick biofilm .
These changes , the stronger the toxicity of MRSA. However , when exposed to higher smoke , tobacco conventional MRSA toxicity. Cigarette smoke -induced changes in surface charge 10 times faster than that of the large electronic cigarette exposure Stranded alter the hydrophobicity , and reactive oxygen species and reduced susceptibility to antimicrobial peptides .
In a mouse model of pneumonia , exposure to tobacco smoke , the survival rate of four times the control lungs and death from MRSA MRSA is more than 30 % of mice significantly . Even in mice with triple survival electronic cigarette vapor exposure MRSA is high, toxic stronger .
Unfortunately, Crotty Alexander , in order to steam also kill pathogens , increased virulence of electronic cigarette vapor bacteria , found to reduce the ability of human epithelial cells .